Interleukin-6, Diabetes, and Metabolic Syndrome in a Biracial Cohort: The Reasons for Geographic and Racial Differences in Stroke Cohort
Authors' conclusion
Although IL-6 was higher in Black than in White participants and those with central adiposity, the association of IL-6 with diabetes risk was statistically significant only among White participants without central adiposity. The association with metabolic syndrome risk was similarly stronger in low-risk groups. The results support the concept of interventions to lower inflammation in diabetes prevention, but to reduce race disparities, better biomarkers are needed.
Study context
- Population
- Black and White adults aged ≥45 years enrolled 2003–2007 in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, at risk of incident diabetes or metabolic syndrome; follow-up ∼9.5 yearsREGARDS enrolled
- Participants
- 30,239 participants
- Exposure
- IL-6 fourth vs first quartile
- Outcome
- Incident diabetes and metabolic syndrome
- Follow-up
- ∼9.5 years
Methodological detailsbiracial cohort, modified Poisson regression
- Biracial cohort
- Modified Poisson regression
Main finding
As reported in the abstract
Incident diabetes by IL-6 quartile, by race and central adiposity
IL-6 Q4 vs IL-6 Q1Relative risk (95% CI)
Black participants with central adiposity
2.02(1.00–4.07)
Black participants without central adiposity
1.66(1.00–2.75)
White participants with central adiposity
1.73(0.92–3.26)
White participants without central adiposity
2.34(1.17–4.66)
- Incident diabetes
- 14%
- Incident metabolic syndrome
- 20%
- Three-way interaction of IL-6, race and central adiposity for incident diabetes
- P = 8 × 10-5
Observational data: associations, not effects.
Further findings
- The pattern was similar for IL-6 and metabolic syndrome
Original publication
Interleukin-6, Diabetes, and Metabolic Syndrome in a Biracial Cohort: The Reasons for Geographic and Racial Differences in Stroke Cohort. Diabetes Care. Published 18 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →