Association Between Age at Diabetes Diagnosis and Subsequent Incidence of Cancer: A Longitudinal Population-Based Cohort
Authors' conclusion
Our findings highlight the necessity of stratifying management for T2DM according to age of diagnosis. As with a range of vascular outcomes, age-standardized cancer risks are greater in earlier compared with later onset T2DM.
Study context
- Population
- Newly diagnosed T2D patients, 2011–2018, Shanghai, Chinanewly diagnosed T2D
- Participants
- 428,568 participants
- Exposure
- Age at T2D diagnosis vs Shanghai general population
- Outcome
- Incidence of overall cancer and 14 site-specific cancers
Methodological detailslongitudinal, comparison with general population
- Longitudinal
- Comparison with general population
Main finding
As reported in the abstract
Overall cancer SIR by age at T2D diagnosis
20-54
1.48
Standardized incidence ratio (SIR) · CI 1.41–1.54
55-59
1.30
SIR · CI 1.25–1.35
60-64
1.19
SIR · CI 1.15–1.23
65-69
1.16
SIR · CI 1.12–1.20
70-74
1.06
SIR · CI 1.02–1.10
≥75
0.86
SIR · CI 0.84–0.89
Observational data: associations, not effects.
Further findings
Overall cancer in all T2D patients
- Overall cancer cases, T2D cohort
- 18,853
- Overall cancer cases, general population
- 582,643
- Age-standardized rate of overall cancer in T2D
- 501 per 100,000 person-years (95% CI 491, 511)
- SIR overall cancer in T2D (1.09, 1.12)
- 1.10
Site-specific cancers
- Similar trends for respiratory, colorectum, stomach, liver, pancreatic, bladder, CNS, kidney, gallbladder cancer and lymphoma, in males and females
Original publication
Association Between Age at Diabetes Diagnosis and Subsequent Incidence of Cancer: A Longitudinal Population-Based Cohort. Diabetes Care. Published 18 January 2024. doi:10.
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