Mortality risk following ischaemic and non‐ischaemic heart failure in people with type 2 diabetes: Observational study in England, 2000–2021
Authors' conclusion
Our findings indicate broadly similar mortality rates in people with ischaemic and non-ischaemic HF, with higher rates in people with type 2 diabetes compared to those without diabetes in both women and men.
Study context
- Population
- Adults with incident heart failure (HF) (ischaemic if following an ischaemic heart disease event, otherwise non-ischaemic), UK Clinical Practice Research Datalink, England, 2000–202118,296 ischaemic HF
- Participants
- 73,344 adults
- Exposure
- T2D vs no diabetes
- Outcome
- All-cause mortality following HF diagnosis
Methodological detailsmatched by sex, year of birth and general practice, linked primary care, hospital and mortality records
- Matched by sex, year of birth and general practice
- Linked primary care, hospital and mortality records
Main finding
As reported in the abstract
All-cause mortality following HF diagnosis (adjusted HR)
HR for mortality, ischaemic HF, women
1.26
1.17–1.36
HR for mortality, ischaemic HF, men
1.23
1.15–1.31
HR for mortality, non-ischaemic HF, women
1.24
1.19–1.29
HR for mortality, non-ischaemic HF, men
1.20
1.15–1.25
Observational data: associations, not effects.
Further findings
Per 100 person-years
| Outcome | Type 2 diabetes | Without diabetes |
|---|---|---|
| Age-standardised mortality rate following ischaemic HF, women | 19.2 (95% CI 18.1–20.3) | 15.1 (CI 14.4–15.8) |
| Age-standardised mortality rate following ischaemic HF, men | 20.4 (CI 19.5–21.4) | 16.5 (CI 15.9–17.1) |
Deaths
- Deaths in ischaemic HF
- 9584
- Deaths in non-ischaemic HF
- 31 800
Age-standardised mortality rates following non-ischaemic HF
- Corresponding rates in non-ischaemic HF
- 19.5 (19.0-20.1), 22.0 (21.4-22.6), 16.6 (16.2-17.0) and 19.4 (18.9-19.8)
Original publication
Mortality risk following ischaemic and non‐ischaemic heart failure in people with type 2 diabetes: Observational study in England, 2000–2021. Diabetes Obes Metab. Published 2 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →