Integrated glycomics and genetics analyses reveal a potential role for N-glycosylation of plasma proteins and IgGs, as well as the complement system, in the development of type 1 diabetes
Authors' conclusion
This study identified novel genetic associations driving the distinct N-glycosylation of plasma proteins and IgGs identified previously at type 1 diabetes onset. Our results highlight the importance of further exploring the potential role of N-glycosylation and its influence on complement activation and type 1 diabetes susceptibility.
Study context
- Population
- Children and adolescents with recent-onset T1D, Danish Registry of Childhood and Adolescent Diabetes455 replication samples
- Participants
- 1,105 children
- Outcome
- Genetic association of 183,546 markers with levels of 24 IgG and 39 plasma protein N-glycan traits
Methodological detailsdiscovery and replication (follow-up) samples
- Discovery and replication (follow-up) samples
Main finding
As reported in the abstract
Novel: rs5757680 (chromosome 22, near MGAT3) with core fucosylated digalactosylated disialylated IgG N-glycan with bisecting GlcNAc
pdiscovery=7.65 × 10-12, preplication=8.33 × 10-6
Novel: rs137702 (near MGAT3) with core fucosylated digalactosylated IgG glycan with bisecting GlcNAc
pdiscovery=2.88 × 10-10, preplication=3.03 × 10-3
Novel: rs1047286 (missense, chromosome 19, C3 gene; high LD with rs2230203) with oligomannose plasma protein N-glycan
pdiscovery=2.43 × 10-11, preplication=8.66 × 10-4
Original publication
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