Insulin Secretion, Sensitivity, and Kidney Function in Young Individuals With Type 2 Diabetes
Authors' conclusion
Youth with type 2 diabetes demonstrated severe β-cell dysfunction that was associated with intraglomerular hypertension and kidney hyperoxia. Similar but attenuated findings were found in OCs.
Study context
- Population
- Youth with T2D (mean age 16 ± 2 years; diabetes duration 2.3 ± 1.8 years; 60% female; median HbA1c 6.4%; BMI 36.4 ± 7.4 kg/m²) and obese and normal-weight controls
- Participants
- 50 / 21 / 20
- Exposure
- Youth with T2D vs obese controls vs normal-weight controls
- T2Dn = 50
- OCsn = 21reference
- NWCsn = 20
- Outcome
- β-cell function, UACR and intraglomerular pressure
Main finding
As reported in the abstract
| Group | Value | ACPRg | UACR | Intraglomerular pressure |
|---|---|---|---|---|
| T2D | 0.6 (IQR 0.0–1.6) × 103 mg/kg lean/min (disposition index (DI)) | 0.6 [0.3, 1.4] nmol/L | 10.3 [5.9, 58.0] mg/g | 77.8 ± 11.5 mmHg |
| OCs | 3.8 (IQR 2.4–4.5) × 103 mg/kg lean/min (DI) | 5.3 [4.3, 6.9] nmol/L | 5.3 [3.4, 14.3] mg/g | 64.8 ± 5.0 mmHg |
Value
T2D0.6 (IQR 0.0–1.6) × 103 mg/kg lean/min (DI)
OCs3.8 (IQR 2.4–4.5) × 103 mg/kg lean/min (DI)
ACPRg
T2D0.6 [0.3, 1.4] nmol/L
OCs5.3 [4.3, 6.9] nmol/L
UACR
T2D10.3 [5.9, 58.0] mg/g
OCs5.3 [3.4, 14.3] mg/g
Intraglomerular pressure
T2D77.8 ± 11.5 mmHg
OCs64.8 ± 5.0 mmHg
- T2D vs OCs: P < 0.0001 — DI lower with T2D
- T2D vs OCs: P < 0.001 — ACPRg lower with T2D
- T2D vs OCs: P = 0.003 — UACR higher with T2D
- T2D vs OCs: P < 0.001 — Intraglomerular pressure higher with T2D
Observational data: associations, not effects.
Further findings
Glomerular filtration rate (GFR) and kidney oxygen availability
- T2D and OCs had higher GFR and kidney oxygen availability (relative hyperoxia) than NWCs
DI and kidney measures
- DI associated inversely with intraglomerular pressure and kidney hyperoxia
Original publication
Insulin Secretion, Sensitivity, and Kidney Function in Young Individuals With Type 2 Diabetes. Diabetes Care. Published 28 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →