Lipids & metabolic liver disease
Insulin resistance, coronary artery lesion complexity and adverse cardiovascular outcomes in patients with acute coronary syndrome
Authors' conclusion
Elevated baseline TyG index and SYNTAX score were associated with a higher risk of MACEs in ACS. Furthermore, the SYNTAX score partially mediated the relationship between the TyG index and adverse cardiovascular outcomes.
Study context
- Population
- Patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI); Insulin resistance (IR) assessed by triglyceride-glucose (TyG) index, lesion complexity by SYNTAX score
- Participants
- 986 patients
- Exposure
- Association of TyG index and SYNTAX score with MACE
- Outcome
- MACE
- Follow-up
- Median 30.72 months
Methodological detailsmediation analysis, adjusted Cox regression, restricted cubic splines
- Mediation analysis
- Adjusted Cox regression
- Restricted cubic splines
Main finding
As reported in the abstract
- MACE cases
- 167
- All-cause deaths
- 66 (6.69%)
- Nonfatal MI
- 26 (2.64%)
- Unplanned revascularizations
- 99 (10.04%)
- Positive dose-response of TyG index with MACE on restricted cubic splines (RCS) (non-linear)
- P = 0.119
- Positive dose-response of SYNTAX score with MACE on RCS (non-linear)
- P = 0.004
Observational data: associations, not effects.
Further findings
Mediation by SYNTAX score of TyG index–MACE association
- Proportion mediated in different adjusted models
- 25.03%, 18.00%, 14.93%, and 11.53%
Mediation by SYNTAX score with unplanned revascularization as endpoint
- Similar mediating effects observed
Original publication
Insulin resistance, coronary artery lesion complexity and adverse cardiovascular outcomes in patients with acute coronary syndrome. Cardiovasc Diabetol. Published 16 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →