Insulin resistance and coronary inflammation in patients with coronary artery disease: a cross-sectional study
Authors' conclusion
The TyG index positively correlated with PCAT attenuation in patients with CAD. The TyG index and PCAT attenuation showed a synergistic correlation with multivessel CAD. Furthermore, PCAT attenuation partially mediated the relationship between the TyG index and CAD severity. Controlling inflammation in patients with high IR and coronary inflammation may provide additional benefits.
Study context
- Population
- Consecutive patients with coronary artery disease (CAD) who underwent coronary angiography and coronary CT angiography, April 2018–March 2023; mean age 62 ± 11 years, 67.8% men
- Participants
- 569 patients
- Exposure
- TyG index and peri-coronary adipose tissue (PCAT) attenuation in relation to CAD severity
- Outcome
- Association of TyG index with PCAT attenuation (proximal right coronary artery (RCA))
Methodological detailsconsecutive patients, mediation analysis
- Consecutive patients
- Mediation analysis
Main finding
As reported in the abstract
Correlation of PCAT attenuation with TyG index (r)
r = 0.166
P < 0.001
Adjusted increase in PCAT attenuation per SD increment in TyG index
1.791 HU
95% CI 0.920–2.662 HUP < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Multivessel CAD | 3.199 (1.826–5.607) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
- Multivessel CAD — Patients with multivessel CAD
- 382 (67.1%)
Mediation of TyG index–multivessel CAD association by PCAT attenuation
- Proportion mediated by PCAT attenuation
- 31.66%
Original publication
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