Insulin Resistance and CGM-Derived Parameters in People With Type 1 Diabetes: Are They Associated?
Authors' conclusion
In people with T1D, an association between IR, measured by eGDR, and worse CGM profiles was observed.
Study context
- Population
- People with T1D; mean age 46 ± 17 years, 55% male; Insulin resistance (IR) by estimated glucose disposal rate (eGDR) or hyperinsulinemic-euglycemic clamp (HEC); glucometrics over 28 days
- Participants
- 287 people
- Exposure
- Lowest vs highest eGDR tertile
- Outcome
- TAR
- Follow-up
- 28 days
Methodological detailsretrospective analysis of 2 databases
- Retrospective analysis of 2 databases
Main finding
As reported in the abstract
P = 0.043
Observational data: associations, not effects.
Further findings
Higher eGDR and glucometric tertiles (logistic regression)
- Higher time in range (TIR)-tertile
- OR 1.251, P < .001
- Lower time above range (TAR)-tertile
- OR 1.281, P < .001
- Higher time below range (TBR)-tertile
- OR 0.893, P = .039
- Adjusted for age, sex, diabetes duration, smoking status, and alcohol intake
Glucometrics vs HEC-determined M-value
- No significant association between glucometrics and M-value (n = 48)
Original publication
Insulin Resistance and CGM-Derived Parameters in People With Type 1 Diabetes: Are They Associated? J Clin Endocrinol Metab. Published 10 January 2024. doi:10.
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