Association of Insulin Resistance With Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes: Systematic Review and Meta-analysis
Authors' conclusion
IR, as calculated by the eGDR, may be an additional risk factor for CVD and all-cause mortality in T1D.
Study context
- Population
- Individuals with T1D; Insulin resistance (IR) calculated by estimated glucose disposal rate (eGDR); PubMed, Embase, Cochrane Library searched to 31 October 2023
- Participants
- 21,930 individuals8 studies
- Comparison
- Per 1-unit increase in eGDR index
- Outcome
- CVD and all-cause mortality
Methodological detailsrandom-effects models
- Random-effects models
Pooled result
As reported in the abstract
median follow-up 10 years
Composite cardiovascular disease (CVD): pooled HR per 1-unit increase in eGDR
0.83
95% CI 0.78–0.90, I2 = 58.9%; 5 studies, n=19,960; 2,149 incident CVD cases
All-cause mortality: pooled HR per 1-unit increase in eGDR
0.84
95% CI 0.81–0.87, I2 = 0%; 5 studies, n=19,403; 1,279 deaths
Original publication
Association of Insulin Resistance With Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes: Systematic Review and Meta-analysis. Diabetes Care. Published 17 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →