Managing Impending Nonsevere Hypoglycemia With Oral Carbohydrates in Type 1 Diabetes: The REVERSIBLE Trial
Authors' conclusion
For some impending NS hypoglycemia episodes, individuals with TID could benefit from CHO intake at a higher BG level.
Study context
- Population
- Individuals with T1D, after inpatient subcutaneous insulin-induced decrease in blood glucose (BG) in the fasting state
- Participants
- 29 individuals
- Comparison
- 16 g oral CHO at plasma glucose (PG) ≤80 or ≤90 mg/dL vs <70 mg/dL
- Primary endpoint
- Time spent in hypoglycemia (<70 mg/dL) after initial CHO intake
Methodological detailsopen-label, inpatient
- Open-label
- Inpatient
Primary result
As reported in the abstract
Duration of hypoglycemic events
≤80 mg/dL vs <70 mg/dL: P = 0.026 · ≤90 mg/dL vs <70 mg/dL: P = 0.002
Further findings
Participants reaching hypoglycemia — ≤80 mg/dL vs <70 mg/dL
P = 0.1201
Required >1 treatment to reach or maintain normoglycemia (≥70 mg/dL)
PG nadir — ≤80 mg/dL vs <70 mg/dL
P = 0.008
| Outcome | P value |
|---|---|
| Participants reaching hypoglycemia≤90 mg/dL vs <70 mg/dL | P < 0.0001 |
| PG nadir≤90 mg/dL vs <70 mg/dL | P = 0.002 |
Safety
- No significant rebound hyperglycemia (>180 mg/dL) within the first hour
Original publication
Managing Impending Nonsevere Hypoglycemia With Oral Carbohydrates in Type 1 Diabetes: The REVERSIBLE Trial. Diabetes Care. Published 9 January 2024. doi:10.
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