Insulin-to-carbohydrate ratio intensification during Ramadan in young people using advanced hybrid closed-loop therapy: A prospective quasi-experimental pilot study
Main finding · Non-fasting TIR (70-180 mg/dL)Result — go to the resultAdjusted difference 10.4 % 95% CI 5.2–15.5Authors' conclusion
Prandial insulin intensification may be a safe strategy worthy of further investigation of its potential to improve glycemic control during Ramadan in young people using ACHL therapy.
Study context
- Population
- Young people with T1D using MiniMed 780G advanced hybrid closed-loop (AHCL), fasting during Ramadan 2025; median age 14.9 years47 analysed
- Participants
- 61 people
- Exposure
- 20% insulin-to-carbohydrate ratio (ICR) intensification from Iftar to Suhoor vs standard care
- Interventionn = 18
- Controln = 29reference
- Outcome
- Non-fasting time in range (TIR) (70-180 mg/dL)
- Follow-up
- Over Ramadan
Methodological detailspre-specified adjusted linear regression, Post-Ramadan attrition: 47 of 61 enrolled analysed
- Pre-specified adjusted linear regression
- Post-Ramadan attrition: 47 of 61 enrolled analysed
Main finding
As reported in the abstract
Adjusted difference
10.4 %
95% CI 5.2–15.5
P = 0.0002
ICR intensificationvs Standard care
adjusted difference 10.4 % (95% CI 5.2–15.5); P = 0.0002
Observational data: associations, not effects.
Safety
Primary safety outcome: non-fasting time below range (TBR) (<70 mg/dL)
- Non-fasting TBR remained low and similar between groups, with no evidence of increased hypoglycemia
Original publication
Insulin-to-carbohydrate ratio intensification during Ramadan in young people using advanced hybrid closed-loop therapy: A prospective quasi-experimental pilot study. Diabetes Res Clin Pract. Published 24 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →