Simplified Meal Management in Adults Using an Advanced Hybrid Closed-Loop System
Authors' conclusion
A simplified meal announcement strategy for adults using the MiniMed 780G system, relying on three increments of a fixed one-step CHO amount, may offer a way to improve glycemic control and ease self-care.
Study context
- Population
- Adults with T1D using the MiniMed 780G advanced hybrid closed-loop (AHCL) system; mean age 45.7 ± 12.4, 71% male; mean baseline HbA1c 6.8% ± 1.2%, time in range (TIR) 67.5% ± 16.7%
- Participants
- 14 adults
- Comparison
- Simplified meal announcement (fixed one-step; multistep) vs precise CHO counting with MiniMed 780G AHCL
- Outcome
- TIR
Methodological detailssequential phases: 13-week precise phase, then two 3- to 4-week simplified meal announcement phases
- Sequential phases: 13-week precise phase, then two 3- to 4-week simplified meal announcement phases
Main finding
As reported in the abstract
Fixed one-step vs Precise: P = 0.12 · Multistep vs Precise: P = 0.02
Further findings
| Outcome | Precise | Fixed one-step | P value |
|---|---|---|---|
| GMI, fixed one-step vs preciseSlightly higher with Fixed one-step | 6.6 ± 0 | 6.8 ± 0.4 | P = 0.01 |
| Level 1 hyperglycemia, fixed one-step vs preciseSlightly more with Fixed one-step | 15.0 ± 7 % | 17.1 ± 8 % | P = 0.05 |
| Level 2 hyperglycemia, fixed one-step vs preciseSlightly more with Fixed one-step | 3.6 ± 3 % | 5.5 ± 5 % | P = 0.04 |
Glucose management indicator (GMI), multistep vs precise
- GMI identical in Multistep and Precise
- 6.6%
Safety
| Outcome | Precise | Fixed one-step | Multistep | P value |
|---|---|---|---|---|
| Level 1 hypoglycemia, fixed one-step vs preciseLess with Fixed one-step | 2.8 ± 2 % | 1.6 ± 1 % | — not stated in the abstract | P = 0.03 |
| Level 2 hypoglycemia, fixed one-step vs preciseLess with Fixed one-step | 0.65 ± 1 % | 0.3 ± 5 % | — not stated in the abstract | P = 0.08 |
| Level 1 hypoglycemia, multistep vs preciseLess with Multistep | 2.8 ± 2 % | — not stated in the abstract | 1.9 ± 1 % | P = 0.01 |
| Level 2 hypoglycemia, multistep vs preciseTrend for less with Multistep | 0.65 ± 1 % | — not stated in the abstract | 0.4 ± 0.7 % | P = 0.08 |
— not stated in the abstract
Original publication
Simplified Meal Management in Adults Using an Advanced Hybrid Closed-Loop System. Diabetes Technol Ther. Published 22 August 2024. doi:10.
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