Influence of Bariatric Surgery on Endothelial and Glycocalyx Biomarkers in Obesity and Type 2 Diabetes
Authors' conclusion
Bariatric surgery is associated with sustained, beneficial alterations in biomarkers of glycocalyx and endothelial function in patients with obesity, both with and without T2D. It is suggested that reduced body weight/fat mass and improved insulin sensitivity are of particular importance for these alterations.
Study context
- Population
- Adults undergoing bariatric surgery (RYGB preceded by a 2-week low-calorie diet), single center in Stockholm, Sweden
- Participants
- 28 vs 33
- Exposure
- Before vs after RYGB, in patients with vs without T2D
- T2Dn = 28
- Without T2Dn = 33reference
- Outcome
- Plasma concentrations of glycocalyx biomarkers (hyaluronan and syndecan-1), E-Selectin, VWF and thrombomodulin
- Follow-up
- 2 years after surgery
Methodological detailssingle-centre, 2-year follow-up
- Single-centre
- 2-year follow-up
Main finding
As reported in the abstract
E-Selectin decreased, geometric mean (CV%) (P < .001)
41 (40) to 24 (61) ng/mL
Syndecan-1 decreased (P < .001)
50 (73) to 38 (81) ng/mL
Von Willebrand factor (VWF) decreased (P < .001)
120 (52) to 103 (45)%
HA increased (P < .001)
25 (96) to 40 (78) ng/mL
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Baseline biomarkers, T2D vs without T2DHigher E-Selectin with T2D | P = 0.041 |
| Biomarker change, T2D vs without T2DE-Selectin initially declined faster with T2D | P < 0.003 |
Baseline biomarkers, T2D vs without T2D
- Other biomarkers did not differ between groups
Biomarkers after low-calorie diet (LCD) · after 2-week LCD
- E-Selectin, syndecan-1 and VWF were reduced
Biomarker change, T2D vs without T2D
- Otherwise biomarker changes did not differ between groups
Predictors of biomarker improvement
- Highest predictive value: decrease in body weight and fat mass and increase in insulin sensitivity (HOMA-IR)
Original publication
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