Pretreatment predictors of weight loss in a 12‐month behavioral obesity treatment: a signal detection analysis of Diet Intervention Examining The Factors Interacting with Treatment Success (DIETFITS)
Authors' conclusion
We found that psychosocial and clinical factors, along with race and ethnicity, successfully differentiated subgroups that varied in their 12-month weight loss. Given the heterogeneity in response to behavioral obesity treatment, these results can help generate hypotheses to move intervention science toward a precision medicine approach by matching individuals to their most suitable obesity treatments.
Study context
- Population
- Adults with overweight or obesity in a 12-month behavioral obesity treatment restricting fat or carbohydrates (DIETFITS trial)
- Participants
- 436 adults
- Comparison
- Healthy low-fat vs healthy low-carbohydrate diet; 51 pretreatment variables as predictors
- Primary endpoint
- Achieving at least 5% weight loss
- Follow-up
- 12 months
Methodological detailssignal detection analysis
- Signal detection analysis
Primary result
As reported in the abstract
At least 5% weight loss
Participants achieving at least 5% weight loss, overall
51%
Subgroups identified through signal detection
8
Original publication
Pretreatment predictors of weight loss in a 12‐month behavioral obesity treatment: a signal detection analysis of DIETFITS. Obesity (Silver Spring). Published 13 February 2025. doi:10.
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