Independent effects of the triglyceride-glucose index on all-cause mortality in critically ill patients with coronary heart disease: analysis of the MIMIC-III database
Authors' conclusion
The TyG index was a strong independent predictor of greater mortality in critically ill patients with CHD. Larger prospective studies are required to confirm these findings.
Study context
- Population
- Critically ill patients with coronary heart disease (CHD) in MIMIC-III, grouped into quartiles of triglyceride-glucose (TyG) index; 65.14% men
- Participants
- 1,618 patients
- Exposure
- TyG index and mortality
- Outcome
- In-hospital all-cause mortality
Methodological detailsMIMIC-III database, multivariable Cox proportional hazards models, restricted cubic splines
- MIMIC-III database
- Multivariable Cox proportional hazards models
- Restricted cubic splines
Main finding
As reported in the abstract
Hospital mortality
Hospital mortality rate (overall)
9.64%
TyG index independently associated with elevated risk of hospital mortality, multivariable Cox HR (95% CI 1.25-2.33), P = 0.001
1.71
Observational data: associations, not effects.
Further findings
- Intensive care unit (ICU) mortality rate (overall)
- 7.60%
- TyG index independently associated with elevated risk of ICU mortality, multivariable Cox HR (95% CI 1.07-2.10), P = 0.019
- 1.50
- Risk increased linearly with increasing TyG index (P for non-linearity = 0.764)
Original publication
Independent effects of the triglyceride-glucose index on all-cause mortality in critically ill patients with coronary heart disease: analysis of the MIMIC-III database. Cardiovasc Diabetol. Published 13 January 2023. doi:10.
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