Incidental hyperglycemia in women at reproductive age and its association with thyrotropin levels: A population-based cohort study in China
Authors' conclusion
This study suggests that DM remains a significant health issue among reproductive-aged women in China, and thyroid dysfunction is associated with an increased risk of hyperglycemia.
Study context
- Population
- Chinese women aged 20–49 years with two Chinese National Free Prepregnancy Checkups within 3 years, 2010–2017
- Participants
- 339,259 women
- Exposure
- Low or high TSH, or developing abnormal TSH, vs normal TSH
- Outcome
- Incidence of DM and impaired fasting glucose (IFG) and association with baseline TSH and TSH changes
Methodological detailsnationwide, population-based, inverse probability of treatment weighting
- Nationwide
- Population-based
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Developing abnormal TSH vs Consistent normal TSHHazard ratio (95 % CI)P value
IFG
1.47(1.35–1.60)
P < 0.001DM
1.82(1.61–2.05)
P < 0.001- Incident diabetes mellitus (DM)
- 3 685 (0.37/100 person-years)
- Incident impaired fasting glucose (IFG)
- 8 954 (0.90/100 person-years)
Observational data: associations, not effects.
Original publication
Incidental hyperglycemia in women at reproductive age and its association with thyrotropin levels: A population-based cohort study in China. Diabetes Res Clin Pract. Published 24 June 2025. doi:10.
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