Diabetes-specific nutritional formulas for tube feeding in patients with hyperglycemia: a systematic review and meta-analysis
Authors' conclusion
Evidence from this review demonstrated that DSNF in tube feeding provides statistically significant improvements in glycemia in both critically ill and long-term care populations with hyperglycemia compared with standard formulas.
Study context
- Population
- Tube-fed patients with hyperglycemia in critical care (5 randomized controlled trials (RCTs), 483 patients) and long-term care (3 RCTs, 137 patients)
- Comparison
- Diabetes-specific nutritional formulas (DSNF) in tube feeding vs standard formulas
- Outcome
- Glycaemic control, DSNF vs standard formulas (meta-analysis)
Methodological detailscritical care and long-term care settings addressed separately
- Critical care and long-term care settings addressed separately
Pooled result
As reported in the abstract
Critical care: mean blood glucose, MD (95% CI), P
−0.54 mmol/L
95% CI −0.78 to −0.31p<0.001
Critical care: CV of glucose, MD (95% CI), P
−6.56%
95% CI −12.55% to −0.57%p=0.032
Critical care: SD of glucose (95% CI), P
−0.77 mmol/L
95% CI −1.49 to −0.06p=0.035
Long-term care: HbA1c (95% CI), P
−0.92%
95% CI −1.72% to −0.13%p=0.023
Further pooled results
Other outcomes
- Findings uncertain due to lack of reporting, inconsistent findings, small samples or lack of overall statistical significance
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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