Incidence of Pediatric Graves’ Disease in the United States: An Epidemiological Analysis of 2007–2022 Outpatient Insurance Claims
Authors' conclusion
This study quantifies and delineates trends in pediatric Graves' disease incidence in the United States. The greatest average incidence rate was observed among female and adolescent patients.
Study context
- Population
- Pediatric patients diagnosed with GD (ICD-9/ICD-10 codes), Merative Marketscan outpatient insurance claims database, US, 2007–2022
- Participants
- 3,377 new diagnoses
- Outcome
- Annual incidence of pediatric GD and its trend
- Follow-up
- 2007–2022
Methodological detailsoutpatient insurance claims database
- Outpatient insurance claims database
Main finding
As reported in the abstract
Average annual incidence of pediatric GD · 16-year study period
Average annual incidence rate
3.33 per 100,000
SD = 0.33
Annual increase in incidence (p = 0.39)
0.042 per 100,000
Observational data: associations, not effects.
Further findings
| Outcome | Values | Estimate | |
|---|---|---|---|
| Average annual incidence by sexFemalevs MaleSignificant | Female 5.04 per 100,000 · Male 1.67 per 100,000 | increase in annual incidence (multivariable regression) 1.69 cases per 100,000 (CI 0.82–2.56) | |
| Average annual incidence by age groupAdolescents (13-17 years)vs Other age groupsSignificant; highest of all age groups | Adolescents (13-17 years) 5.72 per 100,000 | increase in adjusted annual incidence 4.92 cases per 100,000 (CI 3.80–6.04) | |
| −50510Difference, cases per 100,000 (linear scale) |
Annual incidence by insurance plan, geographic region, rural status
- No significant change in annual incidence rate across insurance plan, geographic region, or rural status
Original publication
Incidence of Pediatric Graves’ Disease in the United States: An Epidemiological Analysis of 2007–2022 Outpatient Insurance Claims. Thyroid. Published 22 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →