Impulse control disorders and their relationship with psychopathology in patients treated with cabergoline for hyperprolactinaemia
Authors' conclusion
CAB therapy was associated with a modest but clinically meaningful increase in ICD. Screening tools may support early identification, but positive findings require confirmation through comprehensive clinical assessment.
Study context
- Population
- Patients with prolactin-secreting pituitary adenomas treated with cabergoline for hyperprolactinaemia, and controls
- Participants
- 126 patients
- Exposure
- Cabergoline-treated patients vs controls
- Cabergoline (CAB)n = 63
- CGn = 63reference
- Outcome
- Prevalence of ICD, assessed by the Parkinson's Impulse Control Scale (PICS) as reference diagnostic measure
Methodological detailscontrolled
- Controlled
Main finding
As reported in the abstract
ICD prevalence (PICS)
More than twofold higher prevalence and greater severity in CAB; not statistically significant
Observational data: associations, not effects.
Further findings
- Impulse control disorders (ICD) prevalence restricted to CAB-related cases
- 12.7%
- QUIP diagnostic performance vs Parkinson's Impulse Control Scale (PICS): QUIP sensitivity 71.4% · PPV 41.7%
Treatment characteristics within CAB group
- ICD-positive patients had shorter treatment duration and lower weekly doses
Psychopathology (Mini International Neuropsychiatric Interview (MINI), BSI-53)
- Psychiatric comorbidity in ICD cases
- ≈50%
- No significant differences in MINI or BSI-53 results
Original publication
Impulse control disorders and their relationship with psychopathology in patients treated with cabergoline for hyperprolactinaemia. Pituitary. Published 18 May 2026. doi:10.
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