Impact of time in tight range on all‐cause and cardiovascular mortality in type 2 diabetes: A prospective cohort study
Authors' conclusion
Lower TITR is associated with an increased risk of all-cause and cardiovascular mortality in patients with type 2 diabetes, indicating that tight glycaemic control within the physiological range may be crucial for reducing long-term mortality risk, especially in those with seemingly well-controlled diabetes.
Study context
- Population
- Patients with T2D, time in tight range (TITR) measured by continuous glucose monitoring (CGM) at baseline (% time in 3.9–7.8 mmol/L over 24 h)
- Participants
- 6,061 patients
- Exposure
- Lower vs higher TITR
- Outcome
- All-cause and cardiovascular mortality
- Follow-up
- Median 10.9 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Deaths (all-cause)
- 1898 (31.3%)
- Cardiovascular deaths
- 689 (11.4%)
- Linear relationship of lower TITR with higher all-cause and cardiovascular mortality (restricted cubic spline)
- p for linearity <0.01
- All-cause mortality per 10% decrease in TITR, fully adjusted incl. HbA1c: 4% increased risk
- 95% CI 1.01-1.06
- Cardiovascular mortality per 10% decrease in TITR, fully adjusted incl. HbA1c: 4% increased risk
- 95% CI 1.00-1.08
Observational data: associations, not effects.
Further findings
Subgroups: HbA1c <7.0% and FPG <7.0 mmol/L
- Linear relationship between TITR and all-cause mortality risk sustained in patients with HbA1c <7.0% and FPG <7.0 mmol/L
Original publication
Impact of time in tight range on all‐cause and cardiovascular mortality in type 2 diabetes: A prospective cohort study. Diabetes Obes Metab. Published 27 January 2025. doi:10.
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