Diabetes Risk After Treatment for Childhood and Young Adult Cancer
Authors' conclusion
This evaluation of a hospital-based cohort of patients with CYAC identifies these patients' increased long-term risk of developing diabetes and how this varies temporally according to treatment modalities. Notable contrasts in risk by treatment were detected as early as 10 years after cancer diagnosis. Findings should inform the development of risk-stratified evidence-based screening.
Study context
- Population
- Survivors of childhood and young adult cancer (CYAC) in the UK
- Participants
- 4,238 survivors
- Exposure
- Prespecified treatment exposures vs none
- Outcome
- Diabetes (clinical coding or HbA1c values)
Methodological detailslinked cancer registration and electronic health care data, flexible parametric modeling, standardized cause-specific cumulative incidence functions
- Linked cancer registration and electronic health care data
- Flexible parametric modeling
- Standardized cause-specific cumulative incidence functions
Main finding
As reported in the abstract
Diabetes · median follow-up 14.4 years
Individuals identified with diabetes
163
3.8%
Observational data: associations, not effects.
Further findings
| Outcome | TBI | No TBI | HSCT | No HSCT |
|---|---|---|---|---|
| 40-year CIF of diabetes by TBI | 21.0% (CI 13.8–31.9) | 8.4% (CI 6.1–11.5) | — not stated in the abstract | — not stated in the abstract |
| 40-year CIF of diabetes by HSCT | — not stated in the abstract | — not stated in the abstract | 19.6% (CI 13.4–28.6) | 8.2% (CI 6.0–11.3) |
— not stated in the abstract
- 40-year CIF of diabetes by total body irradiation (TBI): 95% CI
- 40-year CIF of diabetes by hematopoietic stem cell transplant (HSCT): 95% CI
Percent
Allogeneic HSCT
25.7%(CI 17.4–38.0)
Autologous HSCT
7.9%(CI 3.3–19.1)
- 95% CI
Diabetes risk with corticosteroids · 40 years after cancer diagnosis
- Increased risk with corticosteroids
- 7.7%
Original publication
Diabetes Risk After Treatment for Childhood and Young Adult Cancer. Diabetes Care. Published 24 January 2025. doi:10.
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