Circulating Proteomic Profiles Are Associated With Incident Type 2 Diabetes in Asian Populations
Authors' conclusion
Our findings reveal plasma protein profiles linked to the onset of T2D in Asian populations, offering insights into the biological mechanisms of T2D development.
Study context
- Population
- Asian individuals in a Singapore multi-ethnic cohort
- Participants
- 1,659 individuals
- Comparison
- Incident T2D cases vs controls
- Casesn = 539
- Controlsn = 1,120reference
- Outcome
- Association of 4775 plasma proteins with incident T2D
Methodological detailsmulti-ethnic cohort, logistic regression, 2-sample mendelian randomization, colocalization analysis
- Multi-ethnic cohort
- Logistic regression
- 2-sample mendelian randomization
- Colocalization analysis
Main finding
As reported in the abstract
Plasma proteins associated with incident T2D
Proteins associated with incident T2D after adjusting for age, sex and ethnicity
522
Proteins still significantly associated after further adjusting for T2D risk factors (fasting glucose, waist circumference, TG)
17
Proteins (of the 522) whose change between baseline and 6-year follow-up was further associated with incident T2D
205
Observational data: associations, not effects.
Further findings
Causal proteins by 2-sample mendelian randomization
- Plasma proteins suggested to play causal roles in T2D development (GSTA1, INHBC, FGL1)
- 3
- Colocalization evidence supporting GSTA1 and INHBC
Original publication
Circulating Proteomic Profiles Are Associated With Incident Type 2 Diabetes in Asian Populations. J Clin Endocrinol Metab. Published 22 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →