Glucose Lowering through Weight management (GLoW): a randomised controlled trial of the clinical and cost effectiveness of a diabetes education and behavioural weight management programme vs a diabetes education programme in adults with a recent diagnosis of type 2 diabetes
Primary result · Change in HbA1c from baselineResult — go to the resultDifference −0.84 mmol/mol 95% CI −2.99 to 1.31Authors' conclusion
A commercial behavioural weight management programme combined with remote dietary counselling after diagnosis of type 2 diabetes did not improve HbA1c up to 12 months post intervention in this trial. The intervention could help people achieve weight loss and be cost-effective compared with current standard National Health Service care.
Study context
- Population
- Adults (≥18 years) with overweight or obesity (BMI≥25 kg/m²) and T2D diagnosed ≤3 years, from 159 primary care practices in England398 completed 12 months
- Participants
- 577 adults
- Comparison
- Tailored diabetes education and behavioural weight management (DEW) vs standard care diabetes education (DE)
- DEWn = 289
- DEn = 288reference
- Primary endpoint
- Change from baseline in HbA1c
- Follow-up
- Up to 12 months
Methodological detailspragmatic, parallel two-group, 1:1 allocation stratified by gender and diabetes duration, unblinded participants
- Pragmatic
- Parallel two-group
- 1:1 allocation stratified by gender and diabetes duration
- Unblinded participants
Primary result
Change in HbA1c from baseline
Difference
−0.84 mmol/mol
95% CI −2.99 to 1.31
P = 0.44
As reported in the abstract
Further findings
Change in HbA1c from baseline · 6 months
- No evidence of an intervention effect on HbA1c change: difference
- −1.83 [−4.05, 0.40] mmol/mol (95% CI)
Weight · 6 months
- Intervention effect on weight
- −1.77 [−2.86, −0.67] kg (95% CI)
Weight · up to 12 months
- Intervention effect on weight
- −1.38 [−2.56, −0.19] kg (95% CI)
Cost-effectiveness
- DEW cost-effective vs DE in within-trial and lifetime analyses; lifetime incremental cost-effectiveness ratio
- £2290 per quality-adjusted life year gained
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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