Impact of Meal Carbohydrate Content on Postprandial Hyperglycemia During Inpatient Use of Fully Automated Insulin Delivery
Authors' conclusion
In conclusion, during fully AID in hospitalized patients, the risk of postprandial hyperglycemia remained <50% for meals ≤50 g CHO. The CHO tolerance was lowest at breakfast and with concomitant glucocorticoid therapy across all meals.
Study context
- Population
- Hospitalized adults receiving fully automated insulin delivery (AID) (FlorenceD2W-T2 or CamAPS HX)844 postprandial periods
- Participants
- 48 adults
- Primary endpoint
- Impact of meal CHO content on postprandial hyperglycemia
Methodological detailsgeneralized additive regression models
- Generalized additive regression models
Primary result
As reported in the abstract
Postprandial hyperglycemia risk by meal CHO content
- Meal CHO content had a nonlinear effect on postprandial hyperglycemia risk
- P < 0.001
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Postprandial hyperglycemia by mealBreakfastvs LunchMore likely at breakfast | 1.8 (1.2–2.6) | P = 0.006 | |
| Postprandial hyperglycemia by mealBreakfastvs DinnerMore likely at breakfast | 1.5 (1.1–2.2) | P = 0.05 | |
| Postprandial hyperglycemia on days with glucocorticoid administrationGlucocorticoid daysvs Days without glucocorticoidMore frequent with glucocorticoid | 3.3 (2.1–5.1) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Impact of Meal Carbohydrate Content on Postprandial Hyperglycemia During Inpatient Use of Fully Automated Insulin Delivery. Diabetes Technol Ther. Published 25 June 2025. doi:10.
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