Impact of hydrocortisone vs prednisone therapy on postsurgical recovery in patients with endogenous hypercortisolism: a prospective cohort study
Authors' conclusion
Prednisone therapy was associated with better mental health QoL than hydrocortisone at 12 weeks postsurgery in patients with hypercortisolism.
Study context
- Population
- Adults with endogenous hypercortisolism who developed postoperative adrenal insufficiency, 2019–2024
- Participants
- 165 adults
- Exposure
- Prednisone vs hydrocortisone after surgery for endogenous hypercortisolism
- Prednisonen = 64
- Hydrocortisonen = 101reference
- Outcome
- Glucocorticoid withdrawal syndrome (GWS) (weekly AddiQoL) and quality of life (QoL) (SF-36, Cushing QoL)
- Follow-up
- 12 weeks postsurgery
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
QoL improvement adjusted for baseline QoL
Estimate (SF-36 mental component score)
0.33
95% CI 0.04–0.63
Prednisone
Estimate (SF-36 role-emotional limitation)
0.52
95% CI 0.2–0.84
Prednisone
Estimate (SF-36 body pain)
0.31
95% CI 0.07–0.56
Prednisone
Observational data: associations, not effects.
Further findings
Final total daily hydrocortisone equivalent dose · follow-up
- No group differences
Original publication
Impact of hydrocortisone vs prednisone therapy on postsurgical recovery in patients with endogenous hypercortisolism: a prospective cohort study. Eur J Endocrinol. Published 3 May 2025. doi:10.
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