Impact of a very low‐calorie ketogenic diet on metabolic and microbiota outcomes in post‐bariatric patients and bariatric‐Naïve individuals: A comparative pilot study
Authors' conclusion
VLCKD is effective in both BS+ and BS- patients, though metabolic and microbial responses may be less robust post-surgery, possibly due to anatomical and physiological changes. Tailored approaches may be therefore needed to optimize outcomes in post-bariatric patients.
Study context
- Population
- Patients with obesity: weight regain after bariatric surgery or bariatric surgery-naïve
- Participants
- 33 patients
- Comparison
- 8-week very low-calorie ketogenic diet (VLCKD) in post-bariatric patients with weight regain (bariatric surgery (BS)+) vs bariatric surgery-naïve patients (BS-)
- BS+n = 15
- BS-n = 18reference
- Outcome
- Weight loss
- Follow-up
- 8 weeks
Methodological detailspilot, comparative
- Pilot
- Comparative
Main finding
As reported in the abstract
BS+
−6.9%
BS-
−8.3%
Observational data: associations, not effects.
Further findings
Metabolic profile
- BS+ showed slightly less metabolic improvement, particularly in insulin resistance and TG
Gut microbiota composition
- Gut microbiota (GM) composition differed at baseline; VLCKD led to significant changes in both groups
- Microbial diversity and specific taxonomic shifts more pronounced in BS-
Safety
- Mild renal function changes in BS+, within clinically acceptable ranges
Original publication
Impact of a very low‐calorie ketogenic diet on metabolic and microbiota outcomes in post‐bariatric patients and bariatric‐Naïve individuals: A comparative pilot study. Diabetes Obes Metab. Published 10 January 2025. doi:10.
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