Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity
Authors' conclusion
Intraduodenal calcium enhances the effect of intraduodenal Trp to stimulate CCK, GLP-1, and PYY and suppress energy intake in males with obesity.
Study context
- Population
- Males with obesity without T2D (mean ± SD age 27 ± 8 years; BMI 30 ± 2 kg/m²; HbA1c 5.3 ± 0.2%)crossover
- Participants
- 15 males
- Comparison
- Intraduodenal calcium 0, 500 or 1000 mg, each combined with Trp
Methodological detailsdouble-blind, cross-over
- Double-blind
- Cross-over
Primary result
As reported in the abstract
Gut hormones, pyloric pressures and energy intake
- Calcium 1000 mg alone stimulated GLP-1, PYY and pyloric pressures
- all P < .05
- Calcium 1000 mg enhanced the effects of Trp to stimulate CCK, GLP-1 and PYY
- all P < .05
- Greater suppression of energy intake with calcium 1000 mg + Trp
- P = .01
Further findings
Relation to calcium dose
- Energy intake inversely related to calcium dose
- R = −0.64; P = .001
- Plasma CCK directly related to calcium dose
- R = 0.44; P = .05
- Plasma GLP-1 directly related to calcium dose
- R = 0.60; P = .01
- Plasma PYY directly related to calcium dose
- R = 0.83; P = .01
Original publication
Dose-related Effects of Calcium to Enhance the Effects of L-tryptophan on Gut Hormones and Energy Intake in Obesity. J Clin Endocrinol Metab. Published 9 January 2025. doi:10.
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