Hypoglycemia in Children Referred to a Tertiary Care Pediatric Endocrine Clinic: Age-Dependent Etiological Variations
Authors' conclusion
Hypoglycemia etiology in children is heterogeneous and varies by age. Any hypoglycemia measured in a child should be seriously evaluated as 7% are asymptomatic. Workup should be tailored based on age, and clinical, biochemical, and imaging findings. Despite extensive workup, in a significant number of patients the mechanism underlying pediatric hypoglycemia remains an enigma. This emphasizes the unmet needs and challenges in studying pediatric hypoglycemia.
Study context
- Population
- Children (0–18 years old) presenting with hypoglycemia referred to a pediatric endocrine tertiary clinic, 1992–2018
- Participants
- 154 children
- Outcome
- Diagnoses and clinical features of children with hypoglycemia
Methodological detailssingle tertiary pediatric endocrine clinic
- Single tertiary pediatric endocrine clinic
Main finding
As reported in the abstract
Clinical diagnosis
- Ketotic hypoglycemia
- n = 45, 29.2%
- Congenital hyperinsulinemic hypoglycemia
- n = 35, 22.7%
- Transient hyperinsulinemic hypoglycemia
- n = 28, 18.2%
- Metabolic disorder
- n = 14, 9.1%
- Systemic disease/syndrome
- n = 15, 9.7%
- Hormone deficiencies
- n = 8, 5.2%
- Insulinoma
- 2 patients
- No diagnosis elucidated
- 7 (4.5%)
Observational data: associations, not effects.
Further findings
Age at diagnosis
- <1 month old
- 58 (37.7%)
- 1-12 months
- 23 (14.9%)
- 1-6 years
- 58 (37.7%)
- 6-18 years
- 15 (9.7%)
- Hypoglycemia etiology varied among neonates, infants, and children
Asymptomatic hypoglycemia
- Asymptomatic hypoglycemia
- 8 patients
Diagnostic fast (47 completed)
- Became hypoglycemic
- 31
- Significant added diagnostic value
- 14 (29.8%)
Original publication
Hypoglycemia in Children Referred to a Tertiary Care Pediatric Endocrine Clinic: Age-Dependent Etiological Variations. Horm Res Paediatr. Published 22 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →