Hypertension as a Novel Link for Shared Heritability in Age at Menarche and Cardiometabolic Traits
Authors' conclusion
Our study highlights the usefulness of cross-trait analyses for identifying shared etiology between age at menarche and cardiometabolic traits, especially early-onset hypertension. The menarche-related loci may contribute to early-onset hypertension through endocrinological pathways.
Study context
- Population
- Females of Taiwanese ancestry (GWAS); girls in the Taiwan Puberty Longitudinal Study (TPLS)females, Taiwanese ancestry
- Participants
- 59,655 females
- Outcome
- Shared loci between age at menarche and cardiometabolic traits
Methodological detailsconjunction false discovery rate method, pleiotropy analysis
- Conjunction false discovery rate method
- Pleiotropy analysis
Main finding
As reported in the abstract
- Novel loci overlapping age at menarche and cardiometabolic traits, incl. body fat and blood pressure
- 27
Observational data: associations, not effects.
Further findings
Early-onset hypertension in girls with central precocious puberty (TPLS)
- Higher risk of early-onset hypertension with central precocious puberty
- 2-fold
Original publication
Hypertension as a Novel Link for Shared Heritability in Age at Menarche and Cardiometabolic Traits. J Clin Endocrinol Metab. Published 22 February 2023. doi:10.
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