Hormonal staining patterns and clinical outcomes in acromegaly: a 15-year single-center study
Authors' conclusion
Despite higher proliferative activity, GH/PRL adenomas did not demonstrate inferior surgical or medical outcomes compared with GH-only adenomas. Prognosis appears to be driven primarily by anatomical features and cytokeratin patterns, supporting individualized treatment strategies.
Study context
- Population
- Patients with acromegaly who underwent transsphenoidal surgery, 2010–2025
- Participants
- 90 patients
- Exposure
- GH/prolactin (PRL)-positive vs GH-only somatotroph adenomas
- GH-onlyn = 47reference
- GH/PRLn = 39
- Othern = 4
- Outcome
- Postoperative remission
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Postoperative remission, overall
32
35.6%
Observational data: associations, not effects.
Further findings
Postoperative remission by optic chiasm compression (multivariable)
| OR for remission (95% CI) | P value | ||
|---|---|---|---|
| Optic chiasm compressionLower odds of remission; independently associated · multivariable analysis | 0.212 (0.049–0.910) | P = 0.037 | |
| 0.050.21520OR for remission (log scale) |
SSA response by perinuclear CK8/18 staining (multivariable)
| OR for SSA response (95% CI) | P value | ||
|---|---|---|---|
| Perinuclear CK8/18 stainingIndependently associated | 4.839 (1.198–19.540) | P = 0.027 | |
| 0.050.21520OR for SSA response (log scale) |
SSA response by T2-weighted MRI hypointensity (multivariable)
| OR for SSA response (95% CI) | P value | ||
|---|---|---|---|
| T2-weighted MRI hypointensityIndependently associated | 5.464 (1.284–23.250) | P = 0.022 | |
| 0.050.21520OR for SSA response (log scale) |
Biochemical response to SSA therapy
- Patients receiving SSA therapy
- 45
- Achieved biochemical response
- 25 (55.6%)
Ki-67
- Ki-67 higher in GH/PRL adenomas, not associated with treatment outcomes
Original publication
Hormonal staining patterns and clinical outcomes in acromegaly: a 15-year single-center study. Pituitary. Published 18 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →