Hormonal Contraceptive Use Is Associated With a Decreased Incidence of Hypothyroidism
Authors' conclusion
This study of >18 000 women and the risk of developing hypothyroidism demonstrates a protective effect of hormonal contraceptive use. Our data, both unadjusted and adjusted using a logistic model to account for cofounding variables, suggest that the use of hormonal contraception, in any form, decreases the risk of developing hypothyroidism.
Study context
- Population
- Women aged 18 to 45 years, TriNetX databasewith sufficient data
- Participants
- 18,578 women
- Comparison
- Hormonal contraception vs controls
- Estrogen-progestin contraceptive (EPC)n = 5,849
- Progestin-only contraceptive (POC)n = 5,052
- Intrauterine device (IUD)n = 1,000
- Controlsn = 6,677reference
- Outcome
- Diagnosis of hypothyroidism
Methodological detailsTriNetX database, logistic model adjusted for confounding variables
- TriNetX database
- Logistic model adjusted for confounding variables
Main finding
As reported in the abstract
Hypothyroidism
Odds ratio
0.14
POC
Odds ratio
0.12
IUD
Odds ratio
0.30
P < 0.001
EPC
Controls
1.8%
118 of 6677
- Hypothyroidism among those receiving hormonal contraception (all forms)
- 165 (1.4%)
Observational data: associations, not effects.
Original publication
Hormonal Contraceptive Use Is Associated With a Decreased Incidence of Hypothyroidism. Endocr Pract. Published 28 October 2023. doi:10.
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