Associations Between Hypothyroidism and Subclinical Atherosclerosis Among Male and Female Patients Without Clinical Disease Referred to Computed Tomography
Authors' conclusion
There are sex-specific differences in the association of hypothyroidism with subclinical atherosclerosis. The higher risk of coronary plaques but not calcification in male patients was independent of traditional coronary risk factors. The lack of associations in female patients may be related to lower underlying risk of CAD.
Study context
- Population
- Adults referred to 64 multidetector spiral CT, without pre-existing coronary artery disease (CAD); hypothyroidism defined as TSH ≥ 4.5 mU/L
- Participants
- 2,499 adults
- Exposure
- Hypothyroidism vs no hypothyroidism, by sex
- Malen = 1,544
- Femalen = 955
- Outcome
- Sex-specific associations of hypothyroidism with coronary calcification and plaques
Main finding
As reported in the abstract
- Male: hypothyroidism associated with coronary calcium score > 0
- P = .027
- Male: hypothyroidism associated with higher coronary calcium score groups
- P = .032
- Male: hypothyroidism associated with soft plaques
- P = .005
- Male: hypothyroidism associated with calcified plaques
- P = .017
- Male, adjusted for traditional coronary risk factors: coronary plaque, OR
- 1.77 (1.08-2.90), P = .023 (CI)
- Male, adjusted for traditional coronary risk factors: coronary calcium score >0, OR (CI)
- .98 (0.63-1.52), P = .925
Observational data: associations, not effects.
Further findings
Prevalence of hypothyroidism · higher in female; in all patients and those <65 years
P < 0.001
Original publication
Associations Between Hypothyroidism and Subclinical Atherosclerosis Among Male and Female Patients Without Clinical Disease Referred to Computed Tomography. Endocr Pract. Published 27 October 2023. doi:10.
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