Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis
Authors' conclusion
This study provides new insights on the association of gestational FT3 and TT3 with major adverse pregnancy outcomes that form the basis for future studies required to elucidate the effects of thyroid function on pregnancy outcomes. Based on the current study, routine FT3 or TT3 measurements for the assessment of thyroid function during pregnancy do not seem to be of added value in the risk assessment for adverse outcomes.
Study context
- Population
- Mother-child pairs from prospective cohort studies with data on gestational FT3 or TT3
- Participants
- 27,331 vs 16,164
- Comparison
- Gestational FT3 or TT3 levels and adverse obstetric outcomes
- FT3n = 27,331
- TT3n = 16,164
- Outcome
- Adverse obstetric outcomes: preeclampsia, gestational hypertension, preterm and very preterm birth, SGA, LGA
Methodological detailsmixed-effects regression models adjusting for potential confounders
- Mixed-effects regression models adjusting for potential confounders
Pooled result
As reported in the abstract
Adverse obstetric outcomes
TT3Estimate (95% CI)P value
Higher TT3, higher risk
OR per SD of TT3, gestational hypertension 1.20(1.08–1.33)
P = 0.0007Lower TT3 but not FT3 associated with higher risk
OR, very preterm birth 0.72(0.55–0.94)
P = 0.018TT3Mean difference per 1 SD increase in TT3, birth weight, g (95% CI)P value
TT3 but not FT3 positively associated
12.8(6.5–19.1)
P < 0.0001- U-shaped association of FT3 with preeclampsia
- P = 0.0069
- J-shaped association of FT3 with gestational hypertension
- P = 0.029
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Gestational Free and Total Triiodothyronine With Gestational Hypertension, Preeclampsia, Preterm Birth, and Birth Weight: An Individual Participant Data Meta-analysis. J Clin Endocrinol Metab. Published 25 October 2023. doi:10.
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