Preliminary Results of a Double-Blind Randomized Controlled Trial Evaluating the Cardiometabolic Effects of Levothyroxine and Liothyronine Compared to Levothyroxine with Placebo in Athyreotic Low-Risk Thyroid Cancer Patients
Authors' conclusion
In this preliminary report, combination treatment with LT4+LT3 induced favorable changes in cardiovascular parameters of diastolic function without any adverse cardiovascular events.
Study context
- Population
- Athyreotic patients with postsurgical hypothyroidism after low-risk thyroid cancer, without cardiovascular risk factors, on long-term levothyroxine (LT4) monotherapy38 randomized, 24 evaluated
- Comparison
- LT4+liothyronine (LT3) vs LT4+placebo
- Healthy volunteersn = 50
- Primary endpoint
- Effects on heart rate, cardiac rhythm and cardiac morphology and function by ECG and Doppler echocardiography
- Follow-up
- 1 year
Methodological detailsdouble-blind, placebo-controlled, preliminary results, Participants and clinicians remained blinded to treatment allocation
- Double-blind
- Placebo-controlled
- Preliminary results
- Participants and clinicians remained blinded to treatment allocation
Primary result
As reported in the abstract
Diastolic function (E/e' ratio)
- Significant improvement in diastolic function, with positive trend over time, in LT4+LT3 vs LT4+placebo
- LT4+LT3 vs LT4+placebo: P = 0.046
Secondary outcomes
Relationship of free triiodothyronine (fT3) levels with Δ E/e' ratio in LT4+LT3 (univariate) · after combination therapy
- Standardized β coefficient (CI 0.001-1.248), p = 0.050
- 0.603
Safety
Adverse events, incl. tachycardia, arrhythmias, AF · first administration to end of study
- Adverse events
- 0
Original publication
Preliminary Results of a Double-Blind Randomized Controlled Trial Evaluating the Cardiometabolic Effects of Levothyroxine and Liothyronine Compared to Levothyroxine with Placebo in Athyreotic Low-Risk Thyroid Cancer Patients. Thyroid. Published 23 October 2023. doi:10.
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