Higher incidence of cardiovascular-kidney complications in Chinese with youth-onset type 2 diabetes versus youth-onset type 1 diabetes attenuated by control of cardio-metabolic risk factors: A population-based prospective cohort study in Hong Kong
Authors' conclusion
People with youth-onset type 2 diabetes had higher incidence rates of CVD and ESKD than type 1 diabetes. The excess risks in type 2 diabetes were removed after adjusted for cardio-metabolic risk factors.
Study context
- Population
- Chinese with youth-onset diabetes (diagnosed at age < 20 years) with metabolic and complication assessment, Hong Kong Hospital Authority, 2000–2018; followed until 2019
- Participants
- 1,260 vs 1,227
- Exposure
- Youth-onset T2D vs youth-onset T1D
- Type 2 diabetesn = 1,260
- Type 1 diabetesn = 1,227reference
- Outcome
- Incident cardiovascular disease (CVD), end-stage kidney disease (ESKD) and all-cause death
- Follow-up
- Mean 9.2 (T1D) and 8.8 (T2D) years
Methodological detailsmultivariable Cox regression
- Multivariable Cox regression
Main finding
As reported in the abstract
CVD, ESKD and all-cause death
Each group vs type 1 diabetesEstimate (95 % CI)
Type 2 diabetes
HR (CVD) 1.66(1.01–2.72)
Type 2 diabetes
HR (ESKD) 1.96(1.27–3.04)
Type 2 diabetes
HR (death) 1.10(0.72–1.67)
Observational data: associations, not effects.
Further findings
Mortality in youth-onset T2D vs age- and sex-matched general population
- Standardized mortality ratio
- 4.15 [3.28-5.17]
Original publication
Higher incidence of cardiovascular-kidney complications in Chinese with youth-onset type 2 diabetes versus youth-onset type 1 diabetes attenuated by control of cardio-metabolic risk factors: A population-based prospective cohort study in Hong Kong. Diabetes Res Clin Pract. Published 20 May 2023. doi:10.
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