Impact of onset age of type 2 diabetes mellitus on risk of renal complications compared to age‐matched non‐diabetic patients: Two cohort studies in the United Kingdom and Hong Kong
Authors' conclusion
Early-onset T2DM is associated with substantially higher risks of CKD, renal decline, and ESRD, underscoring the need for targeted prevention and management strategies to reduce renal complications in younger patients with T2DM.
Study context
- Population
- Adults without chronic kidney disease (CKD), 2008–2013, United Kingdom (UK) and Hong Kong; 6 age groups at baseline (18–39, 40–49, 50–59, 60–69, 70–79, ≥ 80 years)two cohorts
- Exposure
- T2DM vs no diabetes, by age at T2DM onset
- Outcome
- Renal complications: CKD, renal decline and ESRD
- Follow-up
- Median 11.6 years (UK), 9.7 years (HK)
Methodological detailstwo cohorts (UK and Hong Kong), electronic health records, propensity score fine stratification weights within each age group, Cox regression analyses
- Two cohorts (UK and Hong Kong)
- Electronic health records
- Propensity score fine stratification weights within each age group
- Cox regression analyses
Main finding
As reported in the abstract
Renal complications by age at T2DM onset, UK cohort
Each group vs without diabetesHazard ratio (95% CI)
T2DM onset 18-39 yearsCKD
1.87(1.65–2.11)
T2DM onset 18-39 yearsrenal decline
4.87(4.38–5.40)
T2DM onset 18-39 yearsESRD
4.49(3.03–6.68)
T2DM onset ≥80 yearsCKD
1.26(1.21–1.32)
T2DM onset ≥80 yearsrenal decline
1.66(1.55–1.78)
T2DM onset ≥80 yearsESRD
1.48(1.12–1.96)
Observational data: associations, not effects.
Further findings
Renal complications by age at T2DM onset, Hong Kong (HK) cohort
- Similar trend: risks for all outcomes decreased as age at T2DM onset increased
Original publication
Impact of onset age of type 2 diabetes mellitus on risk of renal complications compared to age‐matched non‐diabetic patients: Two cohort studies in the United Kingdom and Hong Kong. Diabetes Obes Metab. Published 1 September 2025. doi:10.
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