Association between Type 2 Diabetes onset age and risk of cardiovascular disease and mortality: Two cohort studies from United Kingdom and Hong Kong
Authors' conclusion
Young onset of T2DM is associated with a significant impact on cardiovascular health later in life. This highlights the importance of the prevention of DM in young adults.
Study context
- Population
- Adults without cardiovascular disease (CVD), United Kingdom (UK) and Hong Kong electronic health records, 2008–2013; stratified into six age groupsUK and Hong Kong (HK) cohorts
- Exposure
- New-onset T2D vs no T2D, by onset age group
- Outcome
- CVD and mortality
Methodological detailstwo cohorts (UK and Hong Kong), electronic health records, multivariable Cox regression adjusted for baseline characteristics and fine stratification weights
- Two cohorts (UK and Hong Kong)
- Electronic health records
- Multivariable Cox regression adjusted for baseline characteristics and fine stratification weights
Main finding
As reported in the abstract
CVD, UK cohort, by T2D onset age
Hazard ratio (95% CI)
T2DM age 18-39vs Without T2DM age 18-39
3.22(2.80–3.71)
T2DM age 60-69vs Without T2DM age 60-69
1.21(1.15–1.26)
T2DM age ≥ 80vs Without T2DM age ≥ 80
0.99(0.93–1.05)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Mortality, by T2D onset ageT2DM age 18-39vs Without T2DM age 18-39 | 2.41 (2.06–2.83) | |
| Mortality, by T2D onset ageT2DM age 60-69vs Without T2DM age 60-69 | 1.40 (1.34–1.46) | |
| Mortality, by T2D onset ageT2DM age ≥ 80vs Without T2DM age ≥ 80 | 1.12 (1.08–1.16) | |
| 0.20.5125Hazard ratio (log scale) |
HK cohort
- Results from the HK cohort showed a similar pattern
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between Type 2 Diabetes onset age and risk of cardiovascular disease and mortality: Two cohort studies from United Kingdom and Hong Kong. Diabetes Metab. Published 18 January 2025. doi:10.
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