Higher hemoglobin levels are associated with impaired left ventricular global strains in metabolic syndrome: a 3.0 T CMR feature tracking study
Authors' conclusion
Higher Hb levels are significantly associated with more severe LV dysfunction in MetS patients, particularly in those with obesity. Targeted monitoring and management of higher Hb levels in MetS patients may help mitigate further deterioration of cardiac function.
Study context
- Population
- Patients with metabolic syndrome (MetS)254 MetS, 78 controls
- Exposure
- Hemoglobin (Hb) level categories in MetS patients: high Hb vs moderate-normal Hb
- Controlsn = 78
- Outcome
- LV global radial, circumferential and longitudinal strains (LVGRS, LVGCS, LVGLS) by CMR feature tracking
Methodological detailscardiac magnetic resonance feature tracking, sex-, age-, and Hb-matched controls
- Cardiac magnetic resonance feature tracking
- Sex-, age-, and Hb-matched controls
Main finding
As reported in the abstract
Β (LVGRS)
- 4.943
95% CI - 7.673 to - 2.213all p < 0.05
High Hb
Β (LVGCS)
- 2.341
95% CI - 3.608 to - 1.074all p < 0.05
High Hb
Β (LVGLS)
−2.797
95% CI - 4.049 to - 1.546all p < 0.05
High Hb
Observational data: associations, not effects.
Further findings
Restricted cubic spline (RCS): Hb levels and left ventricular (LV) global strains
- Inverted L-shaped associations, significant reductions above Hb threshold
- 143 g/L
- p for nonlinearity
- all p for nonlinearity < 0.05
- Fully adjusted
Subgroup: obesity (non-obese vs obese), β per Hb
- LVGRS β non-obese
- - 0.005 [95% CI - 0.087 to 0.097]
- LVGRS β obese
- −0.087 [95% CI - 0.145 to - 0.030]
- LVGCS β non-obese
- −0.006 [95% CI - 0.045 to 0.034]
- LVGCS β obese
- −0.048 [95% CI - 0.075 to - 0.021]
- LVGLS β non-obese
- −0.011 [95% CI - 0.053 to 0.032]
- LVGLS β obese
- −0.063 [95% CI - 0.089 to - 0.036]
- p for interaction
- all p for interaction < 0.05
- Associations more pronounced with obesity
Original publication
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