Cardiometabolic risk factors and disease trends for atrial fibrillation in individuals with type 1 diabetes: a nationwide registry study
Authors' conclusion
The crude incidence of AF was higher for persons with versus without T1DM, and declined significantly in both groups. Adjusting for data-derived predictors of AF attenuated higher risks, suggesting that the higher AF risk for persons with T1DM is driven by its common comorbidities.
Study context
- Population
- Individuals with T1D between 2001 and 2019 and matched controls without T1D; average age 34.1; 43.2% womenmatched cohort
- Participants
- 36,069 vs 165,705
- Exposure
- T1D vs matched controls without T1D
- T1DMn = 36,069
- Controlsn = 165,705reference
- Outcome
- First occurrence of AF
Methodological detailsmatched controls
- Matched controls
Main finding
As reported in the abstract
Incident AF · 2001–2019
T1DM vs ControlsEstimate (95% CI)
Adjusted for sociodemographic factors
adjusted HR 1.34(1.24–1.46)
Also adjusted for coronary, cerebrovascular, kidney disease and HF
HR 0.95(0.87–1.03)
Observational data: associations, not effects.
Further findings
| Outcome | T1DM | Controls |
|---|---|---|
| AF incidence rate per 100,000 person-years, trend 2001 to 2019 | 671 to 494 per 100,000 person years | 568 to 317 per 100,000 person years |
Atrial fibrillation (AF) incidence rate per 100,000 person-years, trend 2001 to 2019
- Those without CVD at baseline did not display a similar rate reduction over time
Incident AF by number of risk factors at baseline (T1DM vs controls)
- Several risk factors at baseline: HR
- 1.61 (1.07-2.43) (95% CI)
- Zero risk factors: HR (95% CI), non-significant
- 0.60 (0.35-1.04)
Risk factors for incident AF in the T1DM cohort
- First available HbA1c, systolic blood pressure, BMI and eGFR each independently associated with incident AF; clear linear risk increase for several cardiometabolic risk factors
Original publication
Cardiometabolic risk factors and disease trends for atrial fibrillation in individuals with type 1 diabetes: a nationwide registry study. Cardiovasc Diabetol. Published 12 March 2025. doi:10.
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