Higher FSH Level Is Associated With Increased Risk of Incident Hip Fracture in Older Adults, Independent of Sex Hormones
Authors' conclusion
Higher FSH is associated with an increased risk of subsequent hip fracture. Our findings support a growing body of evidence for the direct pleiotropic effects of FSH on bone and for a role for FSH in aging and disability independent of sex hormone levels.
Study context
- Population
- Older adults from the Age, Gene/Environment Susceptibility-Reykjavik cohort295 subcohort + 230 cases
- Exposure
- Higher vs lower baseline FSH level
- Outcome
- Incident hip fracture
- Follow-up
- Within 10 years after baseline
Methodological detailsrandom subcohort stratified by sex, robust weighted Cox proportional hazards models
- Random subcohort stratified by sex
- Robust weighted Cox proportional hazards models
Main finding
As reported in the abstract
Incident hip fracture per sex-specific SD increase in FSH
HR, adjusted for age and sex
1.24
95% CI 1.04–1.48P = .02
HR, further adjusted for estradiol, testosterone and SHBG
1.20
95% CI 1.01–1.44P = .04
Observational data: associations, not effects.
Original publication
Higher FSH Level Is Associated With Increased Risk of Incident Hip Fracture in Older Adults, Independent of Sex Hormones. J Clin Endocrinol Metab. Published 12 October 2024. doi:10.
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