Male–female spatio-temporal differences of age-related bone changes show faster bone deterioration in older women at femoral regions associated with incident hip fracture
Authors' conclusion
Using longitudinal QCT scans of the proximal femur and Computational Anatomy, we provided new insights into the higher fracture rates of the proximal femur in older women compared with men of similar age providing new information on the pathophysiology of osteoporosis.
Study context
- Population
- Older men and age-matched women with no history of fracture, randomly selected from the Age, Gene/Environment Susceptibility-Reykjavik study
- Participants
- 371 vs 305
- Exposure
- Older women vs older men
- Womenn = 371
- Menn = 305reference
- Outcome
- Local changes in vBMD, cortical bone thickness (Ct.Th) and internal bone structure of the left proximal femur on QCT
- Follow-up
- 5.2 ± 0.4 years
Methodological detailsrandom subset of AGES-Reykjavik study, age-matched, computational anatomy (voxel-based morphometry (VBM), surf-SPM, tensor-based morphometry (TBM)), quantitative computed tomography (QCT) of left proximal femur at baseline and follow-up; linear mixed effects models with baseline and time-varying covariates, yielding t-test and p-value statistical maps
- Random subset of AGES-Reykjavik study
- Age-matched
- Computational anatomy (VBM, surf-SPM, TBM)
- QCT of left proximal femur at baseline and follow-up; linear mixed effects models with baseline and time-varying covariates, yielding t-test and p-value statistical maps
Main finding
As reported in the abstract
Local changes in vBMD, Ct.Th and bone structure of the proximal femur · 5.2 ± 0.4 years
- Older women had significantly larger losses in volumetric bone mineral density (vBMD), Ct.Th and structure than older men, in regions where deficiency in these parameters has been associated with incident hip fracture
Observational data: associations, not effects.
Original publication
Male–female spatio-temporal differences of age-related bone changes show faster bone deterioration in older women at femoral regions associated with incident hip fracture. J Bone Miner Res. Published 16 August 2024. doi:10.
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