Parental history of hip fracture is associated with trabecular deterioration
Main finding · Bone density, microarchitecture and estimated bone strengthResult — go to the result% lower femoral neck aBMD 3.8%Authors' conclusion
Individuals with a parental history of hip fracture exhibited significant microarchitectural deterioration, especially in trabecular structure at weight-bearing sites, and reduced estimated bone strength independent of areal BMD.
Study context
- Population
- Ethnically diverse cohort of older adults; mean age 76.1 ± 6.2 yr; 71% female; 55.8% Hispanic
- Participants
- 950 participants
- Exposure
- Parental history of hip fracture vs no parental history
- Parental hip fracturen = 95
- Outcome
- Bone density, microarchitecture and estimated bone strength
Methodological detailsHigh resolution peripheral quantitative computed tomography (HR-pQCT) with individual trabecula segmentation and finite element analysis, propensity-score matched subset
- HR-pQCT with individual trabecula segmentation and finite element analysis
- Propensity-score matched subset
Main finding
As reported in the abstract
% lower femoral neck aBMD
3.8%
P = 0.04
- Radius: lower adjusted trabecular rod BV/TV
- 10.6%
- Radius: lower axial BV/TV
- 12.2%
- Radius: lower plate connectivity (all p < .05)
- 9.5%
- Tibia: lower adjusted trabecular density
- 8.8%
- Tibia: lower trabecular thickness
- 2.4%
- Tibia: lower plate and axial BV/TV (all p < .05)
- 14%-15%
- Tibia: lower estimated stiffness and failure load, persisting after adjustment for aBMD
- 4%-5%
Observational data: associations, not effects.
Further findings
Subgroups and sensitivity analysis
- Patterns similar regardless of race/ethnicity and maternal vs paternal parental hip fracture
- Similar patterns in propensity-score matched subset
Original publication
Parental history of hip fracture is associated with trabecular deterioration. J Bone Miner Res. Published 28 July 2026. doi:10.
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