High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction
Main finding · All-cause deathResult — go to the resultHazard ratio 1.53 95% CI 1.19–1.98Authors' conclusion
A high TyG index is associated with an increased risk of mortality and rehospitalization in patients with HFpEF. The TyG index may serve as a promising prognostic marker for patients with HFpEF.
Study context
- Population
- Patients with heart failure with preserved ejection fraction (HFpEF); TyG index = ln(fasting TG [mg/dL] × fasting glucose [mg/dL]/2)
- Participants
- 823 patients
- Exposure
- Highest vs lowest TyG index tertile
- Outcome
- All-cause death
- Follow-up
- Median 3.16 years
Main finding
As reported in the abstract
Hazard ratio
1.53
95% CI 1.19–1.98
Highest tertilevs Lowest tertile
HR 1.53 (95% CI 1.19–1.98)
- All-cause deaths, overall
- 147 (17.8%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| CV deathMultivariate Cox model | 1.52 (1.19–1.96) | |
| 0.512Hazard ratio (log scale) |
- Cardiovascular (CV) death — CV deaths, overall
- 139 (16.8%)
Heart failure (HF) rehospitalization
- HF rehospitalizations, overall
- 222 (27.0%)
- Association of TyG index with HF rehospitalization, HR (95% CI), competing risk model
- 1.31 (1.07-1.61)
Original publication
High triglyceride-glucose (TyG) index is associated with poor prognosis of heart failure with preserved ejection fraction. Cardiovasc Diabetol. Published 29 September 2023. doi:10.
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