Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study
Authors' conclusion
The present study suggests a potential role for a high and sustainable level of TyG index in the risk of frailty. The trajectories of the TyG index can help to identify older individuals at a higher risk of frailty who deserve primitive preventive and therapeutic approaches.
Study context
- Population
- Older urban residents from the Fujian prospective aging cohort
- Participants
- 1,866 residents
- Exposure
- Triglyceride-glucose (TyG) index trajectory groups
- Low-stablen = 697reference
- Moderate-stablen = 910
- High-stablen = 214
- Outcome
- Prefrailty and frailty risk by TyG index trajectory
- Follow-up
- 10-year follow-up
Methodological detailslongitudinal, 10-year follow-up, group-based trajectory model, multinomial logistic regression
- Longitudinal
- 10-year follow-up
- Group-based trajectory model
- Multinomial logistic regression
Main finding
As reported in the abstract
High-stable vs Low-stableOdds ratio (95% CI)P value
Prefrailty
1.79(1.11–2.88)
P = 0.017Frailty
2.17(1.01–3.88)
P = 0.038Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Frailty risk, cross-sectional, TyG index Q4vs Q1 | 1.50 (1.00–2.25) | P = 0.048 | |
| 0.512Odds ratio (log scale) |
Frailty risk, cross-sectional, TyG index Q4 vs Q1
- Restricted cubic splines showed an increasing trend for TyG index and frailty risk
Subgroup by BMI
- Association of high-stable TyG trajectory with frailty status only in subjects with BMI ≥ 24 kg/m²
One-year ADL/IADL decline, highest vs other TyG quartiles (prospective)
- Highest TyG quartile: significantly increased risk of one-year ADL/IADL decline
- 2.09-fold (P = 0.045)
Original publication
Association of triglyceride-glucose index trajectory and frailty in urban older residents: evidence from the 10-year follow-up in a cohort study. Cardiovasc Diabetol. Published 29 September 2023. doi:10.
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