High triglyceride-glucose index and stress hyperglycemia ratio as predictors of adverse cardiac events in patients with coronary chronic total occlusion: a large-scale prospective cohort study
Authors' conclusion
The study revealed that a high TyG index and a high SHR were significantly correlated with poor prognosis in patients with CTO and suggested that these two biomarkers are reliable in predicting long-term prognosis in CTO patients.
Study context
- Population
- Angina patients with coronary chronic total occlusion (CTO), Fuwai Hospital, January 2017 to December 2018
- Participants
- 2,740 patients
- Exposure
- High vs low triglyceride-glucose (TyG) index and stress hyperglycaemia ratio (SHR)
- Outcome
- Composite of:
- CV death and target vessel MI (TVMI)
- MACCEs (all-cause death, nonfatal MI, ischaemia-driven target vessel revascularization, stroke)
- Follow-up
- Median 3 years
Methodological detailsconsecutive enrolment, single-centre
- Consecutive enrolment
- Single-centre
Main finding
As reported in the abstract
median 3 years
Hazard ratio (95% CI)
High TyG indexvs Low TyG indexCV death/TVMI
4.23(1.58–11.37)
High SHRvs Low SHRCV death/TVMI
5.14(1.89–13.98)
High TyG indexvs Low TyG indexMACCEs
2.47(1.54–3.97)
High SHRvs Low SHRMACCEs
2.91(1.84–4.60)
- MACCEs (whole cohort)
- 179 (6.5%)
- Cardiovascular (CV) death or target vessel myocardial infarction (TVMI) (whole cohort)
- 47 (1.7%)
Observational data: associations, not effects.
Further findings
Predictive value (AUC)
- AUC, TyG index, CV death/TVMI
- 0.623
- AUC, SHR, CV death/TVMI
- 0.589
- AUC, TyG index, MACCEs
- 0.659
- AUC, SHR, MACCEs
- 0.624
- AUC for TyG-SHR combination larger than TyG index alone in predicting MACCE risk
Combined high TyG index and high SHR
- Both high TyG index and high SHR showed the highest risk of clinical outcomes
Original publication
High triglyceride-glucose index and stress hyperglycemia ratio as predictors of adverse cardiac events in patients with coronary chronic total occlusion: a large-scale prospective cohort study. Cardiovasc Diabetol. Published 15 July 2023. doi:10.
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