Epidemiology of the first-ever cardiovascular event in people with type 1 diabetes: a retrospective cohort population-based study in Catalonia
Authors' conclusion
Peripheral artery disease in the whole cohort, and heart failure in elder subjects are the most frequent first-ever CVD events in T1D in our region. These findings deserve to be taken into account when considering primary prevention measures and when estimating CV risk in people with T1D.
Study context
- Population
- Patients with T1D >30 years without cardiovascular disease (CVD) before 2010, SIDIAP database, Catalonia (Spain)
- Participants
- 8,412 patients
- Exposure
- Women vs Men
- Outcome
- First-ever CV event, type of CV event and associations with baseline characteristics
- Follow-up
- Up to end of 2016
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
First CV event
Patients with a first CV event
884
Incidence rate
1.62 per 100 persons-years
Peripheral vascular disease, most frequent first event
39.5%
Observational data: associations, not effects.
Further findings
Heart failure as first CV event, by sex
Baseline factors associated with first CV event
| HR (95% CI) | ||
|---|---|---|
| Decreased glomerular filtration rate | 5.42 (4.32–6.80) | |
| Elevated albumin/creatinine ratio | 3.39 (2.47–4.66) | |
| Microvascular complications | 3.27 (2.85–3.75) | |
| Hypertension | 3.21 (2.80–3.67) | |
| 0.10.31310Hazard ratio (log scale) |
- Heart failure as first CV event, by sex — In women >65 years, HF was the most frequent event
- 40.5%
Baseline factors associated with first CV event
- HbA1c >7.0% associated with incident CVD only in patients aged <55/60 years
Original publication
Epidemiology of the first-ever cardiovascular event in people with type 1 diabetes: a retrospective cohort population-based study in Catalonia. Cardiovasc Diabetol. Published 14 July 2023. doi:10.
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