Impact of diabetes mellitus on disease severity and patient survival in idiopathic pulmonary arterial hypertension: data from the Polish multicentre registry (BNP-PL)
Authors' conclusion
Patients with IPAH and DM present with more advanced pulmonary vascular disease and worse survival than counterparts without DM independently of age, BMI, and cardiovascular comorbidities.
Study context
- Population
- Adults with idiopathic pulmonary arterial hypertension (IPAH) in the Polish BNP-PL registry, 21 reference centres, March 1, 2018–August 31, 2020matched cohort
- Participants
- 532 adults
- Exposure
- IPAH with diabetes mellitus (DM) vs without DM
- DMn = 136
- No DMn = 136reference
- Outcome
- All-cause mortality
- Follow-up
- 30-month follow-up
Methodological detailsnational multicentre prospective registry, propensity score matched 1:1
- National multicentre prospective registry
- Propensity score matched 1:1
Main finding
As reported in the abstract
- DM associated with higher all-cause mortality vs no DM (matched analysis)
- Propensity score matched
Observational data: associations, not effects.
Further findings
Prevalence of DM
- Diagnosed with DM
- 25.6%
Clinical and haemodynamic severity
- DM associated with older age, higher body mass index (BMI), more advanced exertional dyspnea, increased NT-proBNP, larger right atrial area, increased mean right atrial pressure, mean pulmonary artery pressure and pulmonary vascular resistance vs no DM
Original publication
Impact of diabetes mellitus on disease severity and patient survival in idiopathic pulmonary arterial hypertension: data from the Polish multicentre registry (BNP-PL). Cardiovasc Diabetol. Published 13 July 2023. doi:10.
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