High prevalence of retinopathy in young-onset type 2 diabetes and possible sex differences: insights from Norwegian general practice
Authors' conclusion
Retinopathy prevalence was more than twice as high in YOD as in later-onset T2D. The increased likelihood of retinopathy in YOD was partly mediated by higher HbA1c and longer T2D duration, but after accounting for these factors it remained higher in men with YOD.
Study context
- Population
- Adults with T2D in Norwegian general practice, 2014
- Participants
- 10,241 adults
- Exposure
- Young-onset T2D vs later-onset T2D
- Outcome
- Prevalence of YOD and association of age at diabetes diagnosis with retinopathy, overall and in men and women
Methodological detailsgeneral practice electronic medical records, multivariate logistic regression
- General practice electronic medical records
- Multivariate logistic regression
Main finding
As reported in the abstract
Retinopathy
YOD
25%
YOD vs Later-onset T2DOdds ratio (95% CI)
Men; adjusted for age, country of origin, education, BMI
2.6(2.0–3.5)
Women; adjusted for age, country of origin, education, BMI
2.2(1.5–3.0)
Men; further adjusted for diabetes duration and HbA1c
1.8(1.3–2.4)
- Diagnosed before 40 years of age, both sexes
- 10%
Observational data: associations, not effects.
Further findings
Hemoglobin A1c (HbA1c) · 2012 to 2014
- HbA1c increased faster in YOD vs later-onset T2D
- HbA1c at diagnosis higher in men, particularly in YOD
Original publication
High prevalence of retinopathy in young-onset type 2 diabetes and possible sex differences: insights from Norwegian general practice. BMJ Open Diabetes Res Care. Published 2 January 2024. doi:10.
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