High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study
Authors' conclusion
Significant number of asymptomatic SS patients have high coronary artery calcium score and are classified at risk for CAD.
Study context
- Population
- Patients with Sheehan syndrome on stable hormonal replacement treatment except GH, and matched controls
- Participants
- 63 vs 65
- Comparison
- Sheehan syndrome (SS) patients vs matched controls
- SSn = 63
- Controlsn = 65reference
- Outcome
- CAC detected
Methodological detailsage, BMI and parity-matched controls
- Age, BMI and parity-matched controls
Main finding
As reported in the abstract
P = 0.006
Observational data: associations, not effects.
Further findings
At risk by CAC score (CAC > 10)
- High sensitive C reactive protein (hsCRP), apolipoprotein B (ApoB) and Lp(a) concentrations · significantly higher in SS
- P < 0.01
Framingham risk score category
- SS classified as low risk
- 95.2%
- SS classified as intermediate risk
- 4.8%
- All controls classified as low risk
Mean Multi-Ethnic Study of Atherosclerosis (MESA) score
- Significantly higher in SS than controls
Correlations of coronary artery calcium (CAC)
- Fasting blood glucose
- r = .316
- ApoB
- r = .549
- Lp(a)
- r = .310
- Framingham risk score (FRS)
- r = .294
Original publication
High prevalence of coronary artery calcification and increased risk for coronary artery disease in patients with Sheehan syndrome—A case–control study. Clin Endocrinol (Oxf). Published 30 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →