High BMI and the risk for incident type 1 Diabetes Mellitus: a systematic review and meta-analysis of aggregated cohort studies
Authors' conclusion
This systematic review and meta-analysis of high-quality observational cohort studies indicated an association between high BMI and the risk of type 1 diabetes, in a graded manner.
Study context
- Population
- Cohort studies reporting the association between overweight and/or obesity (BMI after age 2 years) and incident T1D; databases searched up to June 20227 studies with BMI categories
- Participants
- 1,690,660 participants
- Comparison
- Overweight, obesity or overweight/obesity vs reference BMI
- Outcome
- Incident T1D
Methodological detailsrandom-effects model, 10 cohort studies met inclusion criteria; 7 classifying BMI into categories were of high quality
- Random-effects model
- 10 cohort studies met inclusion criteria; 7 classifying BMI into categories were of high quality
Pooled result
As reported in the abstract
Pooled relative risk (95% CI)
Overweight3 studies
1.35(0.93–1.97)
Obesity5 studies
2.17(1.75–2.69)
Overweight/obesity2 studies
1.87(1.52–2.29)
- Incident T1D cases
- 1979
Further pooled results
| Outcome | Greater risk (95% CI) |
|---|---|
| Incident T1D with positive islet autoantibodies | 2.55 (1.11–5.86) |
Original publication
High BMI and the risk for incident type 1 Diabetes Mellitus: a systematic review and meta-analysis of aggregated cohort studies. Cardiovasc Diabetol. Published 2 November 2023. doi:10.
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